PW02-036 - Thermosensitive CA2+ assay innate immune cells

PW02-036 - Thermosensitive CA2+ assay innate immune cells

Introduction Temperature has immunomodulatory effects on innate immune cells: incubating monocytes at low temperatures for example increases pro-inflammatory responses after LPS-stimulation. The mechanisms mediating this effect are still unclear. The activity of several ion channels is sensitive to changes in temperature, leading to cytosolic calcium influx. Calcium is universally involved in c...

Cutting Edge: Innate Immune Cells

Innate Immune Cells in Liver Inflammation

Innate immune system is the first line of defence against invading pathogens that is critical for the overall survival of the host. Human liver is characterised by a dual blood supply, with 80% of blood entering through the portal vein carrying nutrients and bacterial endotoxin from the gastrointestinal tract. The liver is thus constantly exposed to antigenic loads. Therefore, pathogenic microo...

Platelet Interaction with Innate Immune Cells.

Beyond their traditional role in haemostasis and thrombosis, platelets are increasingly recognised as immune modulatory cells. Activated platelets and platelet-derived microparticles can bind to leukocytes, which stimulates mutual activation and results in rapid, local release of platelet-derived cytokines. Thereby platelets modulate leukocyte effector functions and contribute to inflammatory a...

Innate immune cells in inflammation and cancer.

The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflamma...